Key Protemix Research Publications

Jüllig M, Chen X, Hickey AJ, Crossman DJ, Xu A, Wang Y, Greenwood DR, Choong YS, Schönberger SJ, Middleditch MJ, Phillips ARJ, Cooper GJS. (2007) Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator. Proteomics Clinical Applications, March 13 [Epub ahead of print]

Lu J, Chan YK, Gamble GD, Poppitt SD, Cooper GJS. (2007) Triethylenetetramine (TETA) and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type-2 diabetic patients. Drug Metabolism and Disposition, 35(2): 221-227

Glyn-Jones S, Song S, Black MA, Phillips AR, Choong SY, Cooper GJ. (2007) Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy:molecular snapshot of a severe myocardial disease. Physiological Genomics, 28:284-293

Gong D, Lu J, Chen X, Choong SY, Zhang S, Chan YK, Glyn-Jones S, Gamble GD, Phillips ARJ, Cooper GJS. (2006) Molecular changes evoked by Triethylenetetramine (TETA) treatment in the extracellular matrix of the heart and aorta in Diabetic rats. Molecular Pharmacology, 70(6):2045-2051

Brown PM, Caradoc-Davies TT, Dickson J, Cooper GJS, Loomes K, Baker EN. (2006) Crystal structure of mouse kidney myo-inositol oxygenase, a novel di-iron oxygenase with a key role in inositol metabolism. Proceedings of the National Academy of Sciences (USA), 103:15032-15037

Zhang S, Liu H, Liu J, Tse CA, Dragunow M, Cooper GJS. (2006) Activation of ATF-2 by p38 MAPK during apoptosis induced by human amylin in pancreatic β-cells. FEBS Journal, 273:3779-3791

Brown P M, Caradoc-Davies T T, Dickson J M, Cooper GJS, Loomes KM, Baker, E.N. (2006) Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Crystallographica:Section F Structural Biology & Crystallography Communications, F62

Konarkowska B, Aitken JF, Kistler J, Zhang S, Cooper GJS. (2006) The aggregation potential of human amylin determines its toxicity towards islet β-cells. FEBS Journal, 273:3614-3624

Wang Y, Lam KS, Chan L, Chan KW, Lam JB, Lam MC, Hoo RC, Mak WW, Cooper GJ, Xu A (2006) Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex. J Biol Chem Apr 18

Cooper GJS (2006) Fates intertwined. Nat Biotechnol 24(3):252-4

Konarkowska B, Aitken JF, Kistler J, Zhang S, Cooper GJS (2005) Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J 272(19):4949-4959

Cooper GJS, Chan YK, Dissanayake AM, Leahy FE, Keogh GF, Frampton CM, Gamble GD, Brunton DH, Baker JR, Poppitt SD (2005). Demonstration of a hyperglycaemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation. Diabetes 54,1468–1476

Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJS, Xu A (2005) Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization dependent manner. J Biol Chem 280(18):18341-7

Cooper GJS, Phillips ARJ, Choong SY, Leonard BL, Crossman DJ, Brunton DH, Saafi ‘EL, Dissanayake AM, Cowan BR, Young AA, Occleshaw CJ, Chan YK, Leahy FE, Keogh GF, Gamble GD, Allen GR, Pope AJ, Boyd PDW, Poppitt SD, Borg TK, Doughty RN, Baker JR (2004) Regeneration of the heart in diabetes mellitus by selective copper chelation. Diabetes 53, 2501-2508

Aitken J, Loomes KM, Konarkowska B, Cooper GJS (2003) Suppression of the conversion of human amylin into insoluble amyloid by polycyclic compounds Biochem J 374, 779-784

Xu A, Wang Y, Keshaw H, Xu LY, Lam KSL, Cooper GJS (2003) The fat-derived hormone adiponectin alleviates alcoholic and non-alcoholic liver diseases in mice. J Clin Invest 112 (1), 91-100

Zhang S, Liu J, MacGibbon G, Dragnow M, Cooper GJS (2002) Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet β-cells. J Mol Biol 324, 271-285

Xu A, Choi K-L, Wang Y, Permana PA, Xu L Y, Bogardus C, and Cooper GJS (2002) Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochem Biophys Res Commun 293,1161-1167

Wang Y, Xu A, Knight C, Xu LY, Cooper GJS (2002) Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 277, 19521-19529

Schonberger SJ, Edgar PF, Faull RLM, Cooper GJS (2001) Proteome analysis of six brain regions in Alzheimer’s Disease: identification of consistent differences between diseased and control brains. Proteomics 1, 1519-1528

Buchanan CM, Phillips RAJ, Cooper GJS (2001) Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet β-cells and enhances insulin secretion. Biochem J 360, 431-439

Wang Y, Xu A, Ye JM, Kraegen EW, Tse CA, Cooper GJS (2001) Altered phosphorylation of P20 occurs in diabetic rats with insulin resistance. Diabetes 50, 1821-1827

Cooper GJS (2001) Amylin: physiology and pathophysiology. In The Handbook of Physiology, Section 7: The Endocrine Pancreas and Regulation of Metabolism. Eds Jefferson LS, Cherrington AD, American Physiological Society, Oxford University Press, New York, NY, Chapter 10

Wang Y, Xu A, Cooper GJS (1999) Amylin evokes phosphorylation of P20 in rat skeletal muscle. FEBS Lett 457(1): 149-152

Zhang S, Liu J, Saafi EL, Cooper GJS (1999) Induction of apoptosis by human amylin in RINm5F islet β-cells is associated with enhanced expression of p53 and p21WAF1/CIP1. FEBS Lett 455, 315-320

Hetterachchi M, Chalkley S, Watkinson A, Choong YS, Heller M, Cooper GJS, Kraegen EW (1997) Rat amylin8-37 enhances insulin action and alters lipid metabolism in normal and insulin resistant rats. Am J Physiol 273, E859-E867

Cooper GJS (1994) Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr Rev 15, 163-201

Cooper GJS (1991) Amylin and insulin co-replacement therapy for insulin-dependent (type 1) diabetes mellitus. Med Hypoth 36, 284-288

Leighton B, Cooper GJS (1990) The role of amylin in the insulin resistance of non-insulin-dependent diabetes mellitus. Trends Biochem Sci 15, 295-299

Molina JM, Cooper GJS, Leighton B, Olefsky JM (1990) Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide. Diabetes 39, 260-265

Leighton B, Foot EA, Cooper GJS, King JM (1989) Calcitonin gene-related peptide-1 (CGRP-1) is a potent regulator of glycogen metabolism in rat skeletal muscle. FEBS Lett 249, 357-361

Roberts AN, Leighton B, Todd JA, Cockburn, D, Schofield PN, Sutton R, Holt S, Boyd Y, Day AJ, Foot EA, Willis AC, Reid KBM, Cooper GJS (1989) Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. Proc Natl Acad Sci USA 86, 9662-9666

Cooper GJS, Day AJ, Willis AC, Roberts AN, Reid KBM, Leighton B (1989) Amylin and the amylin gene: structure, function, and relationship to islet amyloid and to diabetes mellitus. Biochim Biophys Acta 1014, 247-258

Leighton B, Cooper GJS (1988) Pancreatic amylin and calcitonin-gene related peptide cause resistance to insulin in skeletal muscle in vitro. Nature 335, 632-635

Cooper GJS, Leighton B, Dimitriadis GD, Parry-Billings M, Kowalchuk JM, Howland K, Rothbard JB, Willis AC, Reid KBM (1988) Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle. Proc Natl Acad Sci USA 85, 7763-7766

Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987). Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84, 8628-8632